孙琳个人简介

发布者:心理学院发布时间:2025-03-26浏览次数:12

 

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     一、个人简介

    孙琳,博士,教授,现为山东第二医科大学心理学院副院长。山东省高等学校青年创新团队带头人(人才引育计划),全国科学技术名词审定委员会行为医学名词编委会编委,中国心理学会生理心理专业委员会委员等。参编中英文教材9部,承担教育部教学改革项目等教学研究项目4项,参与获得山东省教学成果一等奖4项。获实用新型专利1项,先后承担国家级、省级项目等科研项目12项,累计科研经费360余万元。曾获山东医学科技奖三等奖1项,潍坊市科学技术进步奖二等奖1项、自然科学优秀成果奖1项,参与获得山东省科技进步三等奖1项。在国内外期刊发表学术论文58篇,SCI收录论文37篇。指导硕士研究生17人,目前硕士在读8人。导师邮箱:linsun2013@sdsmu.edu.cn

    二、研究方向

    研究方向为临床心理学,研究领域为应激与心理精神疾病的神经生物学,重点探索创伤后应激障碍(PTSD)的脑神经机制及其调控干预机制。通过综合运用神经影像学、神经生理学、心理学实验以及靶向药物调控等手段,揭示应激相关精神心理疾病大脑结构和功能的变化,及这些变化对个体行为和情绪反应的影响,为临床相关疾病精准治疗提供科学依据。

    三、代表性科研项目

1、山东省高等学校青年创新团队人才引育计划-心理危机脑机制及干预研究创新团队带头人,2022.01-2024.12,第一位,200万元;

2AMPA受体GluA1亚基在PTSD负性情绪的发生及快速靶向干预中的作用(82101588),国家自然科学基金青年项目,2022.01-2024.12,第一位,30万元;

3、基于“前额叶-杏仁核-海马”神经环路的谷氨酸能神经元突触可塑性,探究(2R, 6R)-HNK调控PTSD情绪障碍的分子神经机制(ZR2020MC218),山东省自然科学基金面上项目,2021.01-2023.12,第一位,10万元;

4R-ketamineHCN1离子通道调控创伤后应激障碍的分子机制(ZR2017QH001),山东省自然科学基金青年项目,2017.01-2019.12,第一位,15万元;

5Ketamine对抑郁大鼠前额叶神经可塑性的作用及其机制研究(BS2014YY043),山东省优秀中青年科学家科研奖励基金,2014.12 - 2016.12,第一位,6万元。

    四、代表性论文

1Lianghui Ni, Yanling Xu, Sixuan Dong, Yujia Kong, Hong Wang, Guohua Lu, Yanyu Wang, Qi Li, Changjiang Li, Zhongde Du, Hongwei Sun(通讯作者) and Lin Sun(通讯作者), The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD, Translational Psychiatry, 2020, 10:101.

2Congwen Yang, Yuxuan He, Shuang Ren, Yiqin Ding, Xinru Liu, Xue Li, Hao Sun, Dezhi Jiao, Haolin Zhang, Yingshuai Wang(通讯作者), and Lin Sun(通讯作者).Hydrogen Attenuates Cognitive Impairment in Rat Models of Vascular Dementia by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation, Advanced Healthcare Materials, 2024, 2400400. 

3Luping Gou, Yu Li, Shiqi Liu, Haohan Sang, Jiajun Lan, Jinhong Chen, Ling Wang, Changjiang Li, Bo Lian, Xianqiang Zhang, Hongwei Sun(通讯作者), Lin Sun(通讯作者), (2R,6R)-hydroxynorketamine improves PTSD-associated behaviors and structural plasticity via modulating BDNF-mTOR signaling in the nucleus accumbens, J Affect Disord, 2023: S0165-0327(23)00587-6. 

4Xianqiang Zhang, Yanan Zhao, Yalin Du, Haoran Sun, Wenlei Zhang, Aihong Wang, Qi Li, Changjiang Li, Yanyu Wang, Zhongde Du, Hongwei Sun, Lin Sun(通讯作者), Effect of ketamine on mood dysfunction and spatial cognition deficits in PTSD mouse models via HCN1BDNF signaling, Journal of Affective Disorders, 2021, 286:248-258. 

5Yu Li, YaLin Du, Chen Wang, GuoHua Lu, HongWei Sun, YuJia Kong, WeiWen Wang, Bo Lian, ChangJiang Li, Ling Wang, XianQiang Zhang(通讯作者), Lin Sun(通讯作者),(2R,6R)-hydroxynorketamine acts through GluA1-induced synaptic plasticity to alleviate PTSD-like effects in rat models, Neurobiology of Stress, 2022, 28;21:100503.

6Lanwei Hou, Yirui Qi, Hongwei Sun, Gang Wang, Qi Li, Yanyu Wang, Zuoji Zhang, Zhongde Du, Lin Sun(通讯作者), Applying Ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2018, 86:313-321.  

7Haoran Sun, Xianqiang Zhang, Yujia Kong, Luping Gou, Bo Lian, Yanyu Wang, LiJiang, Qi Li, Hongwei Sun and Lin Sun(通讯作者). Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changesinan Animal Model of PTSD with Sex Differences, Molecular Neurobiology, 2021, 58(4): 1738-1754.

8Zixun Wang, Xinyu Hu, Zhongyi Wang, Jiaming Chen, Ling Wang, Changjiang Li, Jing Deng, Kuitao Yue, Lizhuo Wang, Yujia Kong, Lin Sun(通讯作者), Ketamine alleviates PTSD-like effect and improves hippocampal synaptic plasticity via regulation of GSK-3β/GR signaling of rats, Journal of Psychiatric Research, 2024, 178: 259-269.  

9Xinyu Hu, Lifen Liu, Zixun Wang, Yongjing Sun, Zhi Li, Guorun Zhou, Kuitao Yue, Ling Wang, Bo Lian, Guohua Lu, Changjiang Li(通讯作者), Lin Sun(通讯作者), The potential role of GSK-3β signaling pathway for amelioration actions of ketamine on the PTSD rodent model, Brain Research Bulletin, 2023, 200: 110697. 

10Lifen Liu, Rui Li, Lanxia Wu, Yubo Guan, Miao Miao, Yuxuan Wang, Changjiang Li, Chunyan Wu, Guohua Lu, Xinyu Hu(通讯作者), Lin Sun(通讯作者). (2R,6R)-hydroxynorketamine alleviates PTSD-like endophenotypes by regulating the PI3K/AKT signaling pathway in rats, Pharmacology, Biochemistry and Behavior, 2024, 245:173891.